News
Updates from across the peptide research industry, including science, regulation and market developments.
Retatrutide was designed to activate three related peptide-hormone receptors — GIP, GLP-1 and glucagon. Its discovery paper describes how this single-molecule profile was characterised.
Read articleBPC 157 is a 15-amino-acid synthetic peptide studied mainly in animal models. A look at a representative published study and how to read this literature critically.
Read articleThymosin β4 is a 43-amino-acid peptide first characterised as a major actin-sequestering molecule. Here is what the foundational biochemistry and later reviews describe.
Read articleGHK is a naturally occurring tripeptide with a high affinity for copper. A 2018 review summarised decades of laboratory work, including gene-expression data, on the GHK-Cu complex.
Read articleSynthetic peptides purified by reversed-phase HPLC are commonly isolated as trifluoroacetate salts. A 1999 study showed that residual trifluoroacetate can itself affect cell-based experiments.
Read articleLyophilisation removes water to slow the chemical and physical changes that occur in solution. A widely cited review explains the process, its stresses and what makes a stable dried solid.
Read articleAsparagine and aspartic acid residues can rearrange through a cyclic succinimide intermediate, producing isomers that are hard to separate. A classic 1987 study explains the chemistry.
Read articleReading the amino acid order of a peptide was transformed by a stepwise chemical method published in 1950. Understanding it clarifies what sequence confirmation can and cannot show today.
Read articleAn HPLC purity value says how much of a sample is in the main peak; mass spectrometry tells you whether that peak is the right molecule. Electrospray ionisation, described in 1989, is what made this routine for peptides.
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